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ملحوظة:الاسئلة والاجابات من صفحة قسم الفارما على الفيس
Edited by jody 92, 25 February 2012 - 12:37 PM.
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الاسئلة دى من صفحة قسم الفارما على الفيس
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Can you explain plz this sentence " propranolol is used in Fallot`s Tetralogy cynotic spells ?
this is a sudden onset, progressive event seen in infants with Tetralogy of Fallots. It is associated with progressive
cyanosis, hyperpnea (increased rate and depth of breathing) and disappearance of heart murmur. If not treated in time
it may ultimately lead to DEATH - In a typical case of Tetralogy of Fallot the pressures in the right ventricle and left
ventricle are equal.if the pulmonary stenosis is severe then the right ventricular after load becomes high and hence
the right ventricular pressures become high. If the systemic vascular resistance is low (which is usually the case in TOF
with cyanotic spells) then the shunt flow becomes right to left. This results in progressive cyanosis. Propanolol reduces
dynamic RV outflow obstruction.Slight ↑ in SVR. Blocks hyperpnea response.
ther important measures: Knee chest position and Phenylephrine to increase systemic vascular resistance SVR –
how prazosin cause fluid retention?
The fall in blood pressure is opposed by baroreceptor reflexes causing fluid retention – decrease blood
supply to the kidneys will stimulate the renin angiotensin aldosterone system (RAA) causing more fluid
retention. See figure
what is meaning of prokinetic effect???????
increase Upper GIT Motility without evacuation
why Isoxsuprine produces skeletal muscle V.D.( X) while Isoxsuprine produces smooth muscle V.D. (√).
why Propranolol treats angina by producing coronary VD. (X).
what is Direct α-2 agonist &Indirect α-2 agonist.
Isoxsuprine produces relaxation of skeletal muscle. X
Isoxsuprine produces smooth muscle relaxation. √
Isoxsuprine produces VD. √
Isoxsuprine produces relaxation of skeletal muscle. X
Methyl dopa competes with dopa leading to
formation of methyl noradrenaline, acting as a ‘False transmitter’. Methyl NA stimulates alpha 2 receptors
in brain stem, so methyldopa is not a direct stimulant of alpha 2 receptors.
why Prazosin produces an initial hypertensive effect. X
prazocin is an alpha 1 blocker and direct vasodilator, so it produces hypotension not hypertension
Edited by jody 92, 05 December 2011 - 07:47 PM.
how come>>>> hydrogenation of ergot inc. alpha antagonism ... while dihydroergotamine is VC ?? and
ergotamine already is an alpha agonist VC
ergotamine and ergotoxin are considered
as "partial agonists" on alpha receptors, and dihyrogenation of these drugs reduces markedly the agonistic action of ergotamine (i.e. dihydroergotamine is a weaker Vasoconstrictor than ergotamine) and abolishes completely the agonistic action of ergotoxine (i.e dihydroergotoxine is an alpha blocker causing Vasodilatation
why give serotonine antagonist between attack of migraine &while give sumatriptan(serotongne agonist)
there is a theory stating that the attack of migraine starts with serotonin release from platelets leading to vasoconstriction (aura phase) followed by vasodilatation and edema of blood vessel wall (headache), that's why serotonin antagonisare given for prophylaxis. On the other hand, in acute attacks we need to constrict the dilated blood vessels -back to normal-and this can be done by triptans (as sumatriptan) which stimulate serotonin receptors.
Edited by jody 92, 05 December 2011 - 08:04 PM.
in angina.......decrease Bl.p lead to reflex 1_tachycardia...2_short diastolic coronary perfusion.....3 add beta
blocker or verapamil ,ana mosh fahma rakam 3 momken any explain!!........
beta blockers and verapamil decrease heart rate so one of them is added to nitrate to prevent reflex
is spironolactone used in heat failure ??
i mean that spironolactone cause hyperkalemia
and that supress cardiac properties
and in Mcq book consider that spironolactone is used in severe heart failure
in cases of HF there is excess activity of RAAS leading to secondary hyperaldosteronism, excess
aldosterone leads to: 1-sodium and water retention which increases blood volume and preload, and
edema. 2-cardiac remodeling.Spironolactone-being an aldosterone antagonist -is used in heart failure to:
1-correct hypervolemia and edema. and2- protect the heart against remodeling.
In AutoCoids which drug is used to close patent ductus arteriosus?!
Alprostadil or indomethacin?
yohimbine may increase ABP by blockiing pre-synaptic alpha2 receptors leading to increase in
noradrenaline release, which in turn stimulates post-synaptic alpha1 receptors on blood vessels.
*ACEI are contraindicated in patients with unilateral renal artery stenosis with 2 functioning kidneys (T or
hya mktoba FALSE f 2lwr2 why????????????? tb ma 27na kda hn3ml renal failure f one kidney
This is not generally a problem with unilateral renal artery stenosis because the unaffected kidney can
usually maintain sufficient filtration after ACE inhibition
plz Drs ,,
-what is papilledema ?
- how come !!.. After usage of ACE I >>> COP may increase in pt wiz congestive HF ??
- And why loop diuretic _specially_ is used 2 correct edema as a disadvantage of minoxidil ??
Thnx in advance .
1-papilledema is edema of the optic disc. 2-ACE Is increase COP in HF because they reduce venous return
(by venodilatation) and afterload (by arteriodilatation) and so the heart can pump more blood from the
congested heart and so COP increases 3-loop diuretics are preferred in this case because we need a
potent diuretic to correct salt and water retention caused by vasodilators as minoxidil.
Drs ,, hwa ana lw esta5dmt el ACE Inhibitors lma yekon 7d 3ndh renin 3aly ashn y2ll EL pressure bs hwa
kman byzwdm el renin ,,, kda el renin hyzed awe ? dh kda 3ady ?
no fear of excess renin because AT I (synthesized from angiotensinogen by the effect of renin) will not
be converted into active AT II because ACE is inhibited by the drug.
Hey Drs , in heart HF ezay bnedy B1-agonists o B1 blockers ?
BB (metoprolol-bisoprolol-carvedilol) are given in very small doses to protect the heart against remodelling
in chronic HF, but B1 agonists (dopamine-dobutamine-prenalterol) are given as positive inotropic drugs
especially in acute HF.
Doctors please ..in the MCQ ..Aspirin given during labor acts as tocolytic. and it is answered as true ..bs in the book , Aspirin => decrease PG => uterine relaxation=>delays labor ! so how is it given during labor to delay it ? ..thanks in advance
by dr Amani Nabil
there is a difference between pharmacological action and uses; inspite that aspirin is tocolytic (relax the uterine muscles) but it is not used to delay labour as it has many side effects regarding the mother: bleeding, and fetus: cerebral heamorrhage and may be closure of the ductus arteriosus. Indomethacin is used as tocolytic but with limitations (dose, time and duration of administration).
INDOMETHACIN is indicated for pharmacologic closure of persistent patentductus arteriosus in premature infants (TRUE/FALSE) WHY?
premature infants (TRUE/FALSE) WHY?
el egaba tb2a true 3shan el indome. be2alel el PGE2 ely maintains el ductus arteriosus patent(opened),,so the result is its closure
by dr Amani Nabil
In the neonate, ductal patency is related to continued production of prostaglandin (PG E). This is
particularly true in the premature infant; therefore, prostaglandin inhibition can affect ductal closure.
NSAIDs inhibit the production of prostaglandins by decreasing the activity of cyclooxygenase. The
result is a functional closure of the patent ductus arteriosus (PDA) in 80% of patients.The 2 NSAIDs
prooved to be effective in patent ductus arteriosus are indomethacin and ibuprofen- but indomethacin
has an onset of action within minutes.
Edited by jody 92, 25 February 2012 - 12:03 PM.
1-Cimetidine blocks selectively H2 receptors in the GIT.X
2-PPIs are not advised to be combined with antacids. T
3-Metoclopramide decreases absorption of drugs from the stomach e.g. digoxin. T
4-Synthetic Pg analogue useful in NSAID-induced ulcer.(a.Paracetamol ) or (e. Misoprostol) in match no 1 -a
5- what is Droperidol??
1-Cimetidine blocks H2 receptors everywhere (Stomach-Heart-Blood vessels)
2-because PPIs are activated in acidic medium and antacids will reduce acidity.
3-Metoclopramide decreases absorption of slowly disintegrated drugs as digoxin becuase metoclopramide is a prokinetic agent that accelerates gastric emptying.
4-Misoprostol-not paracetamo;-is the PG analogue
. 5-Droperidol is a D2 blocker used in treatment of psychosis and as antiemetic.)
Edited by jody 92, 13 March 2012 - 09:23 PM.
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